Doctor of Medical Sciences, Professor, Professor of the Russian Academy of Sciences, Academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation
Date of birth: 22.02.1975
Place of birth: Moscow
EDUCATION:
From 1993 to 1999 — I.M. Sechenov Moscow Medical Academy of the Russian Ministry of Health, specialist in the specialty: "General Medicine" (diploma with honors);
From 1999 to 2001 — I.M. Sechenov Moscow Medical Academy of the Russian Ministry of Health, residency in the specialty "Therapy";
From 2001 to 2002 — I.M. Sechenov Moscow Medical Academy of the Russian Ministry of Health, postgraduate study;
2003 — Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation, professional retraining in the specialty "Clinical Pharmacology".
ACADEMIC DEGREE:
2002 — PhD thesis defense on the topic: "Use of stress echocardiography with dobutamine to predict the pharmacodynamic effects of the cardioselective beta-blocker metoprolol in patients with chronic heart failure" (scientific supervisor — V. G. Kukes);
2006 — doctoral thesis defense in the specialty "Pharmacology, clinical pharmacology" (14.03.06) on the topic: "The importance of pharmacogenetic studies of the biotransformation system and transporters for optimizing pharmacotherapy with cardiovascular drugs" (scientific consultant — V. G. Kukes).
ACADEMIC TITLE:
2013 — received the academic title of "Professor in the Department of Clinical Pharmacology" (HAC);
2015 — awarded the title of "Professor of the Russian Academy of Sciences";
2016 — elected as a Corresponding Member of the Russian Academy of Sciences;
2022 — elected as an Academician of the Russian Academy of Sciences in the specialty "Clinical Pharmacology".
SPECIALTY:
- Clinical Pharmacologist
- Therapist
POSITION:
Head of the Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow
PLACE OF WORK:
Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Head of the Department
WORK EXPERIENCE:
From September 1999 to August 2001 — Resident at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov Moscow Medical Academy of the Russian Health Ministry;
From October 2001 to July 2002 — Postgraduate student at the Department of Clinical Pharmacology and Propaedeutics of Internal Medicine, I.M. Sechenov Moscow Medical Academy of the Russian Health Ministry;
From September 2002 to June 2004 — Assistant at the Department of Clinical Pharmacology and Propaedeutics of Internal Medicine, I.M. Sechenov Moscow Medical Academy of the Russian Health Ministry;
From July 2004 to December 2007 — Associate Professor at the Department of Clinical Pharmacology and Propaedeutics of Internal Medicine, I.M. Sechenov Moscow Medical Academy of the Russian Health Ministry;
From December 2007 to August 2013 — Professor at the Department of Clinical Pharmacology and Propaedeutics of Internal Medicine, I.M. Sechenov First Moscow State Medical University;
From September 2013 to the present — Head of the Department of Clinical Pharmacology and Therapy, State Budgetary Educational Institution of Additional Professional Education RMAPO of the Ministry of Health of the Russian Federation;
From January 2015 to April 2019 — Vice-Rector for Development and Innovation, State Budgetary Educational Institution of Additional Professional Education RMAPO of the Ministry of Health of the Russian Federation;
From April 2019 to April 2024 — Rector, Federal State Budgetary Educational Institution of Additional Professional Education RMANPO of the Ministry of Health of the Russian Federation;
From April 2024 to 2025 — Acting Rector, Federal State Budgetary Educational Institution of Additional Professional Education RMANPO of the Ministry of Health of the Russian Federation.
From 2025 to the present — Scientific Director of the World-Class Genomic Research Center “Center for Predictive Genetics, Pharmacogenetics and Personalized Therapy” of the Russian Scientific Center of Surgery named after academician B.V. Petrovsky
SCIENTIFIC INTERESTS:
- clinical pharmacogenetics and pharmacogenomics
- applied aspects of clinical and pharmacological technologies of personalized medicine (pharmacogenetic testing, therapeutic drug monitoring) in diseases of internal organs
- clinical aspects of studying the biotransformation of drugs, including the study of cytochrome P-450 isoenzymes, drug transporters (P-glycoprotein, organic anion and cation transporters)
- molecular mechanisms of pharmacokinetic drug interactions and polypharmacy in clinical practice
- issues of preventing adverse side effects and ensuring drug safety of patients
- fight against polypharmacy and deprescribing in elderly and senile patients
- information technology in clinical pharmacology
- methodology of teaching clinical pharmacology
SCIENTIFIC ACTIVITIES:
Scientific interests of Sychev D.A. include pharmacogenetics, problems of adverse drug reactions, ensuring drug safety, as well as personalized pharmacotherapy of internal diseases using "omics" technologies and the fight against polypharmacy.
He is the author of more than 1,200 publications, of which over 330 have been published in international scientific journals indexed in leading databases. His Hirsch index is 41 according to the Russian Science Citation Index (more than 11,300 citations) y) and 15 according to Scopus (more than 1150 citations). In addition, he has 16 patents.
Key scientific works are devoted to the development and study of "omics" biomarkers - pharmacogenetic, pharmacoepigenomic and pharmacometabolomic, which allow personalizing the use of vital drugs in patients with a wide range of diseases (cardiovascular, mental, respiratory, gastrointestinal, tuberculosis, oncology), including situations of polypharmacy, in order to reduce the risk of side effects. These biomarkers make it possible to evaluate individual characteristics of pharmacokinetics and pharmacodynamics at different levels - from the genome and mechanisms regulating gene expression to the quantitative determination of drugs and their metabolites in biological fluids.
Pharmacogenetic and pharmacogenomic biomarkers are considered "a priori", allowing to predict the effect and safety of drugs before their prescription, while pharmacoepigenomic and pharmacometabolomic are "posterior", reflecting current changes under the influence of therapy.
Under the leadership of D. A. Sychev, algorithms for personalizing therapy for a number of common and socially significant diseases were developed. He participated in the creation and clinical trials of the first domestic direct oral anticoagulant - factor Xa inhibitor tedixaban (dimolegin).
In addition, under his leadership, scientific projects are carried out financed by grants from the Russian Science Foundation, the Russian Foundation for Basic Research and the President of the Russian Federation. He supervised and consulted 48 candidate (including 1 PhD) and 8 doctoral dissertations in pharmacology and clinical pharmacology.
Sychev D. A. is the author and editor of many educational and methodological materials: the textbook "Clinical Pharmacology" (2015, 2018), translated into Kazakh (2019), the National Guide to Clinical Pharmacology (2024), 15 teaching aids, 12 monographs, 12 educational programs and 5 interactive educational modules.
In 2020, he became the coordinator of the working group for the development of a professional standard for a clinical pharmacologist.
Publications are available at the link: https://orcid.org/0000-0002-4496-3680
Public activities
Sychev D. A. holds the position of President of the Society of Pharmacogenetics, Pharmacokinetics and Personalized Therapy (OPPHT, pharmacodenetika.rf), is a member of the Board of the Association of Clinical Pharmacologists and is a member of the Presidium of the National Medical Chamber. He is also the editor-in-chief of the journals Pharmacogenetics and Pharmacogenomics and Pharmateka. He is a member of the editorial boards of a number of specialized scientific publications, including Vestnik RAMS, Rational Pharmacotherapy in Cardiology, Clinical Pharmacology and Therapy, Safety and Risk of Pharmacotherapy, Antibiotics and Chemotherapy, High-Quality Clinical Practice, Patient-Oriented Medicine and Pharmacy, Real Clinical Practice: Data and Evidence, Molecular Medicine, Biomedicine, Modern Rheumatology, Bulletin of the Scientific Center for Medical Applications, and Pharmacy of Kazakhstan.
From 2014 to 2019, D. A. Sychev was a member of the expert council of the Higher Attestation Commission for Therapeutic Sciences in the field of Pharmacology, Clinical Pharmacology. Currently, he holds the positions of Deputy Chairman of the Interdepartmental Council of the Russian Academy of Sciences for Scientific Substantiation and Support of the Drug Policy of the Russian Federation, as well as Deputy Chairman of the Council for Personalized Medicine under the Presidium of the Russian Academy of Sciences (since 2023). He is also a member of the Bureau of the Section of Medical and Biological Sciences of the Department of Medical Sciences of the Russian Academy of Sciences and the RAS Commission on Popularization of Science.
Sychev D. A. is an expert of the Russian Foundation for Basic Research and the Russian Science Foundation, is a member of the Scientific and Practical and Scientific Councils of the Ministry of Health of the Russian Federation. From 2021 to the present, he has been the Chairman of two Dissertation Councils at the Russian Medical Academy of Postgraduate Education: in the specialties "Pharmacology, Clinical Pharmacology" and "Therapy", as well as the Chairman of the Dissertation Council at the Russian Medical Academy of Postgraduate Education in the specialty "Internal Medicine" and a member of the Dissertation Council of Sechenov University in "Pharmacology and Clinical Pharmacology".
For 8 years, he was the consul from Russia and a member of the Executive Committee of the European Association of Clinical Pharmacologists and Pharmacotherapists (EACPT).
Since April 2020, he has held the position of expert head of the Information Center for Pharmacotherapy in Patients with COVID-19 "PharmaCOVID" based at the Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation (https://pharma-covid.rmapo.ru/).
STATE AWARDS:
2008 - became a laureate of the Russian Government Prize in Science and Technology (as part of a team led by V. G. Kukes);
2022 - received the title of "Honored Scientist of the Russian Federation".
DEPARTMENTAL AWARDS:
2009 - became a laureate of the Prize named after N. P. Kravkova RAMS for the best scientific work in pharmacology and toxicology (for the monograph "Metabolism of drugs. Scientific basis of personalized medicine", co-authors: Kukes V. G., Grachev S. V., Ramenskaya G. V.); 2018, 2024
. — twice received gratitude from the Ministry of Health of the Russian Federation;
2020 — awarded the Certificate of Honor of the Federation Council of the Federal Assembly of the Russian Federation;
2020, 2025. — twice awarded the Certificate of Honor of the Russian Academy of Sciences;
2023 — awarded the medal of the Judicial Department of the Supreme Court of the Russian Federation "FOR INTERACTION" of the 2nd degree.
2024 — awarded the Jubilee Medal "300 Years of the Russian Academy of Medical Sciences".
2024 — received a Letter of Gratitude from the Mayor.
2025 — "Excellent Healthcare Worker" badge.
Regional awards and organization awards:
2017 — awarded the jubilee badge in commemoration of the 385th anniversary of Yakutia's accession to the Russian state "for contribution to strengthening statehood, peace and friendship, development of interethnic peace and harmony, for labor achievements and many years of conscientious work";
2022 — awarded the Alexey Leonov Medal (Kemerovo Region Award) "for world-class achievements, outstanding contribution to the development of the Russian Federation and the Kemerovo Region, as well as for the development and implementation of unique innovative projects in various sectors of the economy of the Kemerovo Region";
2025 — awarded the medal "For Services to the Botkin Hospital".
IDENTIFIERS:
CONTACTS:
E-mail: dimasychev@mail.ru
