The cascade of adverse drug reactions in a girl with juvenile myoclonic epilepsy (Clinical case)
Abstract
Carrying of mutations in genes of liver drugs biotransformation increases the risk of developing adverce drugs reactions. Underestimation of the association of clinical manifestations with adverce drugs reactions and their interpretation as a manifestation of a major or new psychoneurological disease can lead to a «pharmacological cascade». This article presents a clinical case of the sequential development of adverce drugs reactions to each of the three prescribed antiepileptic drugs. An incorrect evaluation of adverce drugs reactions led to the unreasonable prescription of polytherapy with antiepileptic drugs and antipsychotics. The problem of identification of adverce drugs reactions and ways to improve the safety of pharmacotherapy of epilepsy are discussed.
About the Authors
E. N. Bochanova
Federal State Budgetary Educational Institution of Higher Education «Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
N. A. Shnayder
Federal State Budgetary Educational Institution of Higher Education «Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
O. S. Shilkina
Federal State Budgetary Educational Institution of Higher Education «Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
D. V. Dmitrenko
Federal State Budgetary Educational Institution of Higher Education «Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Bochanova E.N., Shnayder N.A., Shilkina O.S., Dmitrenko D.V. The cascade of adverse drug reactions in a girl with juvenile myoclonic epilepsy (Clinical case). Pharmacogenetics and Pharmacogenomics. 2017;(1):21-24. (In Russ.)
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