The perspectives of development for pharmacogenetic and pharmacokinetic approaches to personalized use of target therapy in chronic myeloid leukemia

The objective of chronic myeloid leukemia therapy today is the achievement of cytogenetic and molecular remissions. The main problem of the CML therapy is the development of pharmacological resistance on tyrosine kinase inhibitors (TKI). Oraladministration generates a complex step in the pharmacokinetics (PK) of these drugs. Interindividual PK variability is often large and variability observed in response is influencednot only by the genetic heterogeneity of drug targets, but also by the pharmacogenetic backgroundof the patient (e.g. cytochome P450 and ABC transporter polymorphisms), patient characteristics such as adherence to treatment and environmental factors (drug—drug interactions).The appropriate management of oncology patients thus requires careful monitoring of newer targeted therapies and the development of innovative pharmacokinetic and pharmacogenetic approaches to treatment individualization.

chronic myeloid leukemia, therapeutic drug monitoring, pharmacogenetics, pharmacokinetics, pharmacodynamics, tyrosine kinase inhibitors, imatinib, dasatinib, nilotinib, bosutinib, generic imatinib, drug metabolism, drug transporters

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