The economic feasibility of pharmacogenetic-based prescribing of antipsychotics: a review

Pharmacogenetic-based approach is actively implemented into many fields of medicine. According to regulatory documents, the personalized treatment by psychotropic drugs is limited by genetic testing of CYP2D6 polymorphisms when indicated. However, in past years the range of candidate genes, providing for genotype-based prescribing of antipsychotics, was sufficiently enlarged. Overseas experience of research proves that pharmacogenetic testing can increase effectiveness and safety of antipsychotics. But the economic evaluation of genotype-based therapy in psychiatry was not yet received. Authors of existing algorithms of genotyping have conducted own research, but results of such studies must be considered with caution due to the conflict of interests. The problem is that the available literature does not include enough number of evidence-based pharmacoeconomic analyses of usefulness pharmacogenetic testing in order to prescribe antipsychotics. The present review consider the modern state of question about economic feasibility of personalized prescribing of antipsychotics and dose. The limitations of published research were discussed in order to avoid those in further studies including those, which will be conducted in Russia.

pharmacoeconomics, antipsychotics, pharmacogenetics, genotyping, effectiveness, safety, personalized medicine, psychopharmacotherapy

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