Ethnic differences in the distribution of allele and genotype frequencies for polymorphic markers rs1801275 gene IL-4R, associated with the development of drug allergy in the application of β-lactam antibiotics

Abstract

Objective: to determine the frequency of alleles and genotypes of polymorphic markers rs1801275 gene IL-4Rα, associated with the development of drug allergy β-lactam antibiotics in europeoids populations in Moscow region and the Republic of Dagestan. All study participants were identified genotypes at polymorphic markers rs1801275 gene IL-4Rα by allele-specific PCR (polymerase chain reaction) after prior isolation of DNA (deoxyribonucleic acid) from whole blood leukocytes. As a result of the study determined the frequencies of alleles and genotypes of polymorphic markers rs1801275 gene IL-4Rα in europeoids populations of Moscow region (A — 0,668, G — 0,332; A / A — 0.394, A / G — 0,548, G / G — 0,058) and Republic of Dagestan (A — 0,5375, G — 0,4625; A / A — 0.15 A / G — 0,775, G / G — 0,075). It is shown that such factors as ethnicity may influence the distribution of alleles and genotypes of polymorphic markers rs1801275 gene IL-4Rα, and, consequently, the genetically determined predisposition to the development of drug allergy in the application of β-lactam antibiotics.