Sex differences as a platform for understanding the pharmacological status of women
Abstract
There are still many gaps in the understanding of sex-related differences in drug action. These differences are important since they are potentially affecting the clinical effectiveness of the therapy or impacting on its side effects. It has been established that side effects produced by drugs are more frequent in women than in men. Sex-based effects usually involve differences in pharmacokinetics (i.e., the way the drug is absorbed, distributed, metabolized, and excreted) or pharmacodynamics (the relationship between drug effect and drug concentration at the site of action). Sex-based medicine could be the first step in offering individualized or personalized medicine that would consider individual differences both in basic science and in clinical practice.
About the Authors
O. V. Reshetko
V.I. Razumovsky Saratov State Medical University
Russian Federation
Russian Federation
K. A. Lutsevich
V.I. Razumovsky Saratov State Medical University
Russian Federation
Russian Federation
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For citations:
Reshetko O.V., Lutsevich K.A. Sex differences as a platform for understanding the pharmacological status of women. Pharmacogenetics and Pharmacogenomics. 2015;(1):4-11. (In Russ.)
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