Genetic prerequisites for reducing serum retinol concentration
https://doi.org/10.24411/2588-0527-2019-10036
Abstract
This article discusses the metabolism of vitamin A, significant genes that play an important role in the metabolism of vitamin A and single-nucleotide substitutions in them, associated with a low concentration of vitamin A in the blood and various diseases. Also reviewed the current recommendations on nutrition and drug treatment of hypovitaminosis.
About the Authors
E. M. Zelenskaya
Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences (ICBFM SB RAS)
Russian Federation
Russian Federation
Zelenskaia Elena – junior researcher laboratories of personalized medicine. SPIN-code: 5792-0076
Novosibirsk
G. I. Lifshits
Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences (ICBFM SB RAS)
Russian Federation
Russian Federation
Lifshits Galina – MD, professor, head of the laboratory of personalized medicine. SPIN-code: 9704-1601
Novosibirsk
References
1. Belevtsov YuP, Perepadya SV, Moiseenko AS, et al. Clinical and diagnostic vitamin insufficiency importance in patients with colorectal cancer. Novoobrazovanie. 2011;2(8):98–103. (In Russ).
2. Humphrey JH, Agoestina T, WuL, et al. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr. 1996;128: 489–496. PMID:8618182
3. Soares-Mota M, Silva TA, Gomes LM, et al. High prevalence of vitamin A deficiency in Crohn’s disease patients according to serum retinol levels and the relative dose-response test. World J Gastroenterol. 2015;21(215):16141620. DOI: 10.3748/wjg.v21.i5.1614
4. Strokova OA, Kremleva EA, Konstantinova OD. Impact of intravaginal action of α-tocopherol, retinol acetate, and ascorbic acid on a change in the composition of the lower reproductive tract microflora in young women. Rossiiskii vestnik akushera-ginekologa. 2014;16(6):65–69. (In Russ).
5. Rahmathullah L, Tielsch JM, Thulasiraj RD, et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ. 2003;327: 254–259. DOI: 10.1136/bmj.327.7409.254
6. Esteban-Pretel G, Marín MP, Renau-Piqueras J, et al. Vitamin A deficiency alters rat lung alveolar basement membrane: Reversibility by retinoic acid. J. Nutr. Biochem. 2010;21:227–236. DOI: 10.1016/j.jnutbio.2008.12.007
7. Lounder DT, Khandelwal P, Dandoy CE,. et al. Lower levels of vitamin A are associated with increased gastrointestinal graft-versus-host disease in children. Blood. 2017 May 18; 129(20):2801–2807. DOI: 10.1182/blood-2017-02-765826
8. Tanumihardjo SA, Russell RM, Stephensen CB, et al. Biomarkers of Nutrition for Development (BOND)—Vitamin A Review. J Nutr. 2016 Sep;146(9):1816S–1848S. DOI: 10.3945/jn.115.229708
9. WHO. Global prevalence of vitamin A deficiency in populations at risk: 1995–2005. WHO Global Database on Vitamin A Deficiency. Geneva (Switzerland): WHO; 2009. (https://apps.who.int/iris/bitstream/handle/10665/44110/9789241598019_eng.pdf по состоянию на 10.08.19)
10. Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006;66:606–630. DOI:10.1002/neu.20242
11. Kam RKT, Deng Y, Chen Y, Zhao H. Retinoic acid synthesis and functions in early embryonic development. Cell Biosci. 2012;2:11. DOI:10.1186/2045-3701-2-11
12. Dietologiia 4-e izd / Pod red. AIU Baranovskogo. SPb. Piter; 2012. (In Russ).
13. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996;10:940–954. PMID:8801176
14. Sun H, Kawaguchi R. The membrane receptor for plasma retinolbinding protein, a new type of cell-surface receptor. Int Rev Cell Mol Biol. 2011;288:1–41. DOI:10.1016/B978-0-12-386041-5.00001-7
15. Lobo GP, Hessel S, Eichinger A, et al. ISX is a retinoic acid-sensitive gatekeeper that controls intestinal β, β-carotene absorption and vitamin A production. FASEB J. 2010 Jun; 24(6):1656–1666. DOI: 10.1096/fj.09-150995
16. Leung WC, Hessel S, Mеplan C, et al. Two common single nucleotide polymorphisms in the gene encoding beta-carotene 15,15’-monoxygenase alter beta-carotene metabolism in female volunteers. FASEB J. 2009 Apr;23(4):1041–1053. DOI: 10.1096/fj.08-121962
17. Lietz G, Oxley A, Leung W, Hesketh J. Single nucleotide polymorphisms upstream from the β-carotene 15,15’-monoxygenase gene influence provitamin A conversion efficiency in female volunteers. J Nutr. 2012 Jan;142(1):161S–5S. DOI: 10.3945/jn.111.140756
18. Mondul AM, YuK, Wheeler W, et al. Genome-wide association study of circulating retinol levels. Hum Mol Genet. 2011. Dec 1;20(23):4724–4731. DOI: 10.1093/hmg/ddr387
19. Abraham R, Moskvina V, Sims R, et al. A genome-wide association study for late-onset Alzheimer’s disease using DNA pooling. BMC Med Genomics. 2008 Sep 29;1:44. DOI: 10.1186/1755-8794-1-44
20. Lee JJ, Wu X, Hildebrandt MA, et al Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients. Cancer Prev Res (Phila). 2011 Feb; 4(2):185–193. DOI: 10.1158/1940-6207.CAPR-10-0125
21. Nair AK, Sugunan D, Kumar H, Anilkumar G. Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. PLoS One. 2010 Jul 6;5(7):e11444. DOI: 10.1371/journal.pone.0011444
22. WHO. Serum retinol concentrations for determining the prevalence of vitamin A deficiency in populations. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, 2011 (WHO/ NMH/NHD/MNM/11.3) (http://www.who.int/vmnis/indicators/retinol_ru.pdf, по состоянию на 10.08.19).
23. Food Labeling: Revision of the Nutrition and Supplement Facts Labels Food and Drug Administration, 2016 (https://www.federalregister.gov/documents/2016/05/27/2016-11867/food-labeling-revision-of-thenutrition-and-supplement-facts-labels по состоянию на 10.08.19).
24. Sergeev AV, Anan’ev VS, Kapitanov AB. Pharmacokinetics of carotenoids and carotene containing compounds. Rossiysky Bioterapevtichesky Zhurnal. 2017;16(3):92–101. (In Russ). DOI: 10.17650/1726-9784-2017-16-3-92-101
25. Ofitsialnaia instruktsiia k retinola palmitatu. (In Russ). (https://www.rlsnet.ru/tn_index_id_5073.htm по состоянию на 10.08.19)
26. Ofitsialnaia instruktsiia k izotretinoinu. (In Russ). (https://www.rlsnet.ru/tn_index_id_2820.htm по состоянию на 10.08.19)
Review
For citations:
Zelenskaya E.M., Lifshits G.I. Genetic prerequisites for reducing serum retinol concentration. Pharmacogenetics and Pharmacogenomics. 2019;(1):12-16. (In Russ.) https://doi.org/10.24411/2588-0527-2019-10036
Views:
1966
Email this article 
Post a Comment 