The study of the activity of isoenzymes of cytochrome P450 for the prediction of drug-drug interactions of medicines in terms of polypharmacy
Abstract
Isozymes of cytochrome P450 enzymes are major catalyzing phase I biotransformation drugs that usually leads to the formation of hydrophilic and little active metabolites. The greatest role drugs play biotransformation CYP3A4, CYP2D6, CYP2C9, CYP2C19 and CYP1A2. Inhibition and induction of cytochrome P450 under the influence of drugs is an important and clinically relevant mechanism pharmacokinetics drug interactions. Study of the activity of isoenzymes of cytochrome P450 using phenotyping methods (determination of the concentration of specific substrates and metabolites thereof biological fluids) against application of drugs to predict adverse drug reactions resulting from drug-drug interactions. Promising for clinical practice is the use of phenotyping for the cytochrome P450 is not exogenous and endogenous substances (eg the ratio of cortisol / 6-beta-hydroxycortisol in urine to evaluate the activity of CYP3A4), which is the most safe and minimally invasive approach to research participants.
About the Authors
D. A. Sychev
FSBEI FPE Russian Medical Academy of Continuous Professional Education of Ministry of Healthcare of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
V. A. Otdelenov
FSBEI FPE Russian Medical Academy of Continuous Professional Education of Ministry of Healthcare of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
N. P. Denisenko
FSBEI FPE Russian Medical Academy of Continuous Professional Education of Ministry of Healthcare of the Russian Federation,
Russian Federation
Moscow
Russian Federation
Moscow
V. V. Smirnov
First Moscow State Medical University named after I.M. Sechenov; NRC Institute of Immunology FMBA of Russia
Russian Federation
Moscow
Russian Federation
Moscow
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For citations:
Sychev D.A., Otdelenov V.A., Denisenko N.P., Smirnov V.V. The study of the activity of isoenzymes of cytochrome P450 for the prediction of drug-drug interactions of medicines in terms of polypharmacy. Pharmacogenetics and Pharmacogenomics. 2016;(2):4-11. (In Russ.)
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