Pharmacogenetics and clinical studies: common ground
Abstract
Pharmacogenetics and clinical trials developed independently for decades. Nowadays it becomes apparent that genetic testing and the pharmacogenetic are necessary for the clinical studies to ensure effective and safe treatment. At the initial stages of clinical trials of the experimental groups we exclude volunteers and/or patients who have pharmacokinetic and pharmacodynamic differences by genetic testing. Conversely, later phases of clinical trials we to examine the efficacy and safety in the samples of patients with genetically determined differences from the norm.
About the Authors
R. E. Kazakov
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
N. G. Berdnikova
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation; I.M. Davidovckiy City Clinical Hospital №23
Russian Federation
Russian Federation
D. A. Sychev
State Funded Educational Institution Russian Medical Academy of Postgraduate Education Studies of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Kazakov R.E., Berdnikova N.G., Sychev D.A. Pharmacogenetics and clinical studies: common ground. Pharmacogenetics and Pharmacogenomics. 2016;(1):18-23. (In Russ.)
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