Pharmacogenetics of arterial hypertension: pharmacogenetic of torasemide
Abstract
The article discusses the pharmacogenetics of arterial hypertension and pharmacological response to antihypertensive drugs, in particular the influence of pharmacogenetic polymorphism of different genes in the efficacy and safety of new loop diuretic torasemide. A review of the scientific evidence on the influence of genetic polymorphisms of genes metabolizsing enzyme CYP2C9 and anion transporter OAT on the pharmacokinetics of the drug (hepatic and renal clearance) and the pharmacodynamics (pronounced of diuretic and saluretic effects).
About the Author
M. V. Leonova
Russian stste medical university
Russian Federation
Russian Federation
Department of Clinical Pharmacology
Moscow
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Review
For citations:
Leonova M.V. Pharmacogenetics of arterial hypertension: pharmacogenetic of torasemide. Pharmacogenetics and Pharmacogenomics. 2016;(1):4-8. (In Russ.)
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