Cough and angioedema from angiotensin-converting enzyme inhibitors: genetic markers
Abstract
While coughing remains the most frequent adverse drugs reaction (ADR) when taking ACE inhibitors, angioedema giving him a frequency is considered to be the most threatening complication from this group of drugs. The risk of such complications are usually associated with increased levels of bradykinin and it`s active metabolites by inhibiting ACE. Genetic factors associated with the level of ACE in plasma and the incidence of complications play a leading role. To search for genetic markers usually used mapping candidate. This method allows analyzing ADR due to gene polymorphism. The present review consider the relationship of polymorphisms in candidate genes with the frequency of ADR of the ACE inhibitor. In addition, we discuss the possible causes of isolated visceral angioedema.
About the Authors
I. S. Dantsev
Russian State Academy of Postgraduate Education
Russian Federation
Russian Federation
I. I. Sinitsina
Russian State Academy of Postgraduate Education
Russian Federation
Russian Federation
D. A. Sychev
Russian State Academy of Postgraduate Education
Russian Federation
Russian Federation
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Review
For citations:
Dantsev I.S., Sinitsina I.I., Sychev D.A. Cough and angioedema from angiotensin-converting enzyme inhibitors: genetic markers. Pharmacogenetics and Pharmacogenomics. 2015;(2):9-13. (In Russ.)
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