phgenomicsФармакогенетика и фармакогеномикаPharmacogenetics and Pharmacogenomics2588-05272686-8849LLC "Izdatelstvo OKI"10.24411/2588-0527-2018-10002phgenomics-41Research ArticleАКТУАЛЬНЫЕ ОБЗОРЫCURRENT REVIEWЗначение полиморфизма в генах KCNJ11, ABCC8 и TCF7L2 для ответа на терапию основными группами пероральных сахароснижающих препаратовThe value polymorphism in gen KCNJ11, ABCC8 and TCF7L2 for response to therapy of the main oral hypoglycemic drugsШороховаПолина БорисовнаShorokhovaP. B.poliamina@gmail.comЗагородниковаКсения АлександровнаZagorodnikovaK. A.noemail@neicon.ruБарановВиталий ЛеонидовичBaranovV. L.noemail@neicon.ruВорохобинаНаталья ВладимировнаVorokhobinaN. V.noemail@neicon.ruФГБОУ ВО СЗГМУ им. И.И. Мечникова Минздрава РоссииРоссияNorth-Western State Medical University named after I.I. MechnikovRussian Federation20181203201801914Copyright © Шорохова П.Б., Загородникова К.А., Баранов В.Л., Ворохобина Н.В., 20182018Шорохова П.Б., Загородникова К.А., Баранов В.Л., Ворохобина Н.В.Shorokhova P.B., Zagorodnikova K.A., Baranov V.L., Vorokhobina N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/41

В обзоре представлена накопленная на настоящий момент научная информация о значении и принципах действия основных пероральных сахароснижающих препаратов в лечении сахарного диабета, и роли полиморфных вариантов в генах KCNJ11, ABCC8 и TCF7L2, исходно признанных ответственными за предрасположенность к заболеванию сахарным диабетом, в индивидуальном ответе на терапию пероральными сахароснижающими препаратами. Приведён обзор функций кодируемых указанными генами белков, охарактеризованы основные полиморфные варианты, представлены основные опубликованные научные исследования и обозначены направления для дальнейших научных изысканий.

In review accumulated present scientific information about the value and principles of action of main oral hypoglycemic drugs in treatment of diabetes mellitus (DM), and the role of polymorphic variants in the genes KCNJ11, ABCC8 and TCF7L2, recognized source responsible for the predisposition to the DM, individual response to treatment with oral hypoglycemic agents. Reviewed the functions of proteins encoded by these genes, main polymorphic variants, indicated directions for further scientific research.

сахарный диабетпероральные сахароснижающие препаратыKCNJ11ABCC8TCF7L2полиморфизмdiabetes mellitusoral hypoglycemic agentsKCNJ11ABCC8TCF7L2polymorphismReferencesInternational Diabetes Federation (IDF). IDF Diabetes Atlas. 2017;8th edition: 7-11.International Diabetes Federation (IDF). IDF Diabetes Atlas. 2017;8th edition: 7-11.Аметов А.С. Сахарный диабет 2 типа. Проблемы и решения. - М.: ГЭОТАР-Медиа; 2017.Аметов А.С. Сахарный диабет 2 типа. Проблемы и решения. - М.: ГЭОТАР-Медиа; 2017.DeFronzo RA. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009 Apr;58(4):773-795. DOI: 10.2337/db09-9028DeFronzo RA. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009 Apr;58(4):773-795. DOI: 10.2337/db09-9028Дедов И.И., Шестакова М.В., Аметов А.С. и др. Консенсус совета экспертов Российской ассоциации эндокринологов по инициации и интенсификации сахароснижающей терапии у больных сахарным диабетом 2 типа // Сахарный диабет. - 2011. - Т. 14. - № 4. - С. 6-17.Дедов И.И., Шестакова М.В., Аметов А.С. и др. Консенсус совета экспертов Российской ассоциации эндокринологов по инициации и интенсификации сахароснижающей терапии у больных сахарным диабетом 2 типа // Сахарный диабет. - 2011. - Т. 14. - № 4. - С. 6-17.Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. - 8-й выпуск. - М.: Уп ПРИНТ; 2017. Сахарный диабет. - 2017; - 20(1S). - С.1-112.Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. - 8-й выпуск. - М.: Уп ПРИНТ; 2017. Сахарный диабет. - 2017; - 20(1S). - С.1-112.Российские клинические рекомендации. Эндокринология / Под ред. И.И. Дедова, Г.А. Мельниченко. - М.: ГЭОТАР-Медиа; 2016. - С. 531-556.Российские клинические рекомендации. Эндокринология / Под ред. И.И. Дедова, Г.А. Мельниченко. - М.: ГЭОТАР-Медиа; 2016. - С. 531-556.Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes care. 2008;31:1-11.Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes care. 2008;31:1-11.Inzucchi SE, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015 Aug;38(8):e128-129. DOI: 10.2337/dc15-0812Inzucchi SE, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015 Aug;38(8):e128-129. DOI: 10.2337/dc15-0812Viollet B., Guigas B., Sanz Garcia N., et al. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond). 2012 Mar;122(6): 253-270. DOI: 10.1042/CS20110386Viollet B., Guigas B., Sanz Garcia N., et al. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond). 2012 Mar;122(6): 253-270. DOI: 10.1042/CS20110386Bailey C. J., Wilcock C., Scarpello J. H. Metformin and the intestine. Diabetologia. 2008 Aug;51(8):1552-1553. DOI: 10.1007/s00125-008-1053-5Bailey C. J., Wilcock C., Scarpello J. H. Metformin and the intestine. Diabetologia. 2008 Aug;51(8):1552-1553. DOI: 10.1007/s00125-008-1053-5Madiraju AK, Erion DM, Rahimi Y., et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014 Jun 26;510(7506):542-546. DOI: 10.1038/nature13270Madiraju AK, Erion DM, Rahimi Y., et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014 Jun 26;510(7506):542-546. DOI: 10.1038/nature13270Prager R., Shernthaner G., Graf H. Effect of metformin on peripheral insulin sensitivity innon insulin dependent diabetes mellitus. Diabetes Metab. 1986;12(6):346-350.Prager R., Shernthaner G., Graf H. Effect of metformin on peripheral insulin sensitivity innon insulin dependent diabetes mellitus. Diabetes Metab. 1986;12(6):346-350.Bailey CJ. The current drug treatment landscape for diabetes and perspectives for the future. Clin Pharmacol Ther. 2015 Aug;98(2):170-184. DOI: 10.1002/cpt.144Bailey CJ. The current drug treatment landscape for diabetes and perspectives for the future. Clin Pharmacol Ther. 2015 Aug;98(2):170-184. DOI: 10.1002/cpt.144Rodbard HW, Jellinger PS, Davidson JA, et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology Consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. EndocrPract. 2009 Sep-0ct;15(6):540-559. DOI: 10.4158/EP.15.6.540Rodbard HW, Jellinger PS, Davidson JA, et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology Consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. EndocrPract. 2009 Sep-0ct;15(6):540-559. DOI: 10.4158/EP.15.6.540Дедов И.И., Шестакова М.В., Аметов А.С. и др. Консенсус совета экспертов Российской ассоциации эндокринологов (РАЭ) по инициации и интенсификации сахароснижающей терапии СД 2 типа // Сахарный диабет. - 2011. - №1. - С. 95-105.Дедов И.И., Шестакова М.В., Аметов А.С. и др. Консенсус совета экспертов Российской ассоциации эндокринологов (РАЭ) по инициации и интенсификации сахароснижающей терапии СД 2 типа // Сахарный диабет. - 2011. - №1. - С. 95-105.Вaggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007 May;132(6):2131-2157. DOI: 10.1053/j.gastro.2007.03.054Вaggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007 May;132(6):2131-2157. DOI: 10.1053/j.gastro.2007.03.054Kim W., Egan J. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008 Dec;60(4):470-512. DOI: 10.1124/pr.108.000604Kim W., Egan J. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008 Dec;60(4):470-512. DOI: 10.1124/pr.108.000604Perfetti R. The role of GLP-1 in the regulation of the islet cell mass. Medscape Diabet Endocrinol. 2004;6(2):134-138.Perfetti R. The role of GLP-1 in the regulation of the islet cell mass. Medscape Diabet Endocrinol. 2004;6(2):134-138.Gautier JF, Choukem SP, Girard J. Physiology of incretins (GIP and GLP-1) and abnormalities in Type 2 diabetes. Diabetes Metab. 2008 Feb;34 Suppl 2:S65-72. DOI: 10.1016/S1262-3636(08)73397-4Gautier JF, Choukem SP, Girard J. Physiology of incretins (GIP and GLP-1) and abnormalities in Type 2 diabetes. Diabetes Metab. 2008 Feb;34 Suppl 2:S65-72. DOI: 10.1016/S1262-3636(08)73397-4Nauck M.A. Incretin-based therapies for Type 2 diabetes mellitus: properties, functions, and clinical implications. Am J. Med. 2011 Jan;124 (1 Suppl):S3-18. DOI: 10.1016/j.amjmed.2010.11.002Nauck M.A. Incretin-based therapies for Type 2 diabetes mellitus: properties, functions, and clinical implications. Am J. Med. 2011 Jan;124 (1 Suppl):S3-18. DOI: 10.1016/j.amjmed.2010.11.002Weyer C., Bogardus C., Mott DM, et al. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin Invest. 1999 Sep;104(6):787-94. DOI: 10.1172/JCI7231Weyer C., Bogardus C., Mott DM, et al. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin Invest. 1999 Sep;104(6):787-94. DOI: 10.1172/JCI7231Клиническая фармакология: национальное руководство / Под ред. Ю.Б. Белоусова, В.Г. Кукеса, В.К. Лепахина, В.И. Петрова. - М.: ГЭОТАР-Медиа; 2009.Клиническая фармакология: национальное руководство / Под ред. Ю.Б. Белоусова, В.Г. Кукеса, В.К. Лепахина, В.И. Петрова. - М.: ГЭОТАР-Медиа; 2009.Рациональная фармакотерапия заболеваний эндокринной системы и нарушений обмена веществ. 2-е изд. / Под общ. ред. И.И. Дедова, Г.А. Мельниченко. - М.: ГЭОТАР-Медиа; 2013.Рациональная фармакотерапия заболеваний эндокринной системы и нарушений обмена веществ. 2-е изд. / Под общ. ред. И.И. Дедова, Г.А. Мельниченко. - М.: ГЭОТАР-Медиа; 2013.Серединин С.Б. Лекции по фармакогенетике. - М.: Издательство МИА; 2004. - С. 12-48.Серединин С.Б. Лекции по фармакогенетике. - М.: Издательство МИА; 2004. - С. 12-48.Сычев Д.А. Фармакогенетическое тестирование: клиническая интерпретация результатов. - М.: 2011. - С. 8-15.Сычев Д.А. Фармакогенетическое тестирование: клиническая интерпретация результатов. - М.: 2011. - С. 8-15.Клиническая фармакогенетика: учебное пособие / Под ред. В.Г. Кукеса, Н.П. Бочкова. - М.: ГЭОТАР-Медиа; 2007.Клиническая фармакогенетика: учебное пособие / Под ред. В.Г. Кукеса, Н.П. Бочкова. - М.: ГЭОТАР-Медиа; 2007.Aguilar-Bryan L., Bryan J. Molecular biology of adenosine triphosphate - sensitive potassium channels. Endocr Rev. 1999 Apr;20(2):101-135. DOI: 10.1210/edrv.20.2.0361Aguilar-Bryan L., Bryan J. Molecular biology of adenosine triphosphate - sensitive potassium channels. Endocr Rev. 1999 Apr;20(2):101-135. DOI: 10.1210/edrv.20.2.0361Seino S., Miki T. Physiological and pathophysiological roles of ATP-sensitive K+ channels. ProgBiophys Mol Biol. 2003 Feb;81(2):133-176.Seino S., Miki T. Physiological and pathophysiological roles of ATP-sensitive K+ channels. ProgBiophys Mol Biol. 2003 Feb;81(2):133-176.Flanagan SE, Clauin S., Bellanne-Chantelot C., et al. Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat. 2009 Feb;30(2):170-180. DOI: 10.1002/humu.20838Flanagan SE, Clauin S., Bellanne-Chantelot C., et al. Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat. 2009 Feb;30(2):170-180. DOI: 10.1002/humu.20838James C., Kapoor RR, Ismail D., et al. The genetic basis of congenital hyperinsulinism. J. Med Genet. 2009 May;46(5):289-299. DOI: 10.1136/jmg.2008.064337James C., Kapoor RR, Ismail D., et al. The genetic basis of congenital hyperinsulinism. J. Med Genet. 2009 May;46(5):289-299. DOI: 10.1136/jmg.2008.064337Thomas P., Ye Y., Lightner E. Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. Hum Mol Genet. 1996 Nov;5(11):1809-1812.Thomas P., Ye Y., Lightner E. Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. Hum Mol Genet. 1996 Nov;5(11):1809-1812.Gloyn AL, Pearson ER, Antcliff JF, et al. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N. Engl J. Med. 2004 Apr 29;350(18):1838-1849. DOI: 10.1056/NEJMoa032922Gloyn AL, Pearson ER, Antcliff JF, et al. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N. Engl J. Med. 2004 Apr 29;350(18):1838-1849. DOI: 10.1056/NEJMoa032922Florez JC, Jablonski KA, Kahn SE, et al. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Diabetes. 2007 Feb;56(2):531-536. DOI: 10.2337/db06-0966Florez JC, Jablonski KA, Kahn SE, et al. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Diabetes. 2007 Feb;56(2):531-536. DOI: 10.2337/db06-0966Lang VY, Fatehi M., Light PE. Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. Pharmacogenet Genomics. 2012 Mar;22(3):206- 214. DOI: 10.1097/FPC.0b013e32835001e7Lang VY, Fatehi M., Light PE. Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. Pharmacogenet Genomics. 2012 Mar;22(3):206- 214. DOI: 10.1097/FPC.0b013e32835001e7Fatehi M., Raja M., Carter C., et al. The ATP-sensitive K. (+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity. Diabetes. 2012 Jan;61(1):241-249. DOI: 10.2337/db11-0371Fatehi M., Raja M., Carter C., et al. The ATP-sensitive K. (+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity. Diabetes. 2012 Jan;61(1):241-249. DOI: 10.2337/db11-0371Florez JC, Hirschhorn J., Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet. 2003;4:257-291. DOI: 10.1146/annurev.genom.4.070802.110436Florez JC, Hirschhorn J., Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet. 2003;4:257-291. DOI: 10.1146/annurev.genom.4.070802.110436Gloyn AL, Hashim Y., Ashcroft SJ, et al. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53). Diabet Med. 2001 Mar;18(3):206-212.Gloyn AL, Hashim Y., Ashcroft SJ, et al. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53). Diabet Med. 2001 Mar;18(3):206-212.Nikolac N., Simundic AM, Katalinic D., et al. Metabolic control in type 2 diabetes is associated with sulfonylurea receptor-1 (SUR-1) but not with KCNJ11 polymorphisms. Arch Med Res. 2009 Jul;40(5):387-392. DOI: 10.1016/j.arcmed.2009.06.006Nikolac N., Simundic AM, Katalinic D., et al. Metabolic control in type 2 diabetes is associated with sulfonylurea receptor-1 (SUR-1) but not with KCNJ11 polymorphisms. Arch Med Res. 2009 Jul;40(5):387-392. DOI: 10.1016/j.arcmed.2009.06.006Ragia G., Tavridou A., Petridis I., et al. Association of KCNJ11E23K gene polymorphism with hypoglycemia in sulfonylurea-treated type 2 diabetic patients. Diabetes Res Clin Pract. 2012 Oct;98(1):119-124. DOI: 10.1016/j.diabres.2012.04.017Ragia G., Tavridou A., Petridis I., et al. Association of KCNJ11E23K gene polymorphism with hypoglycemia in sulfonylurea-treated type 2 diabetic patients. Diabetes Res Clin Pract. 2012 Oct;98(1):119-124. DOI: 10.1016/j.diabres.2012.04.017Sato R., Watanabe H., Genma R., et al. ABCC8 polymorphism (Ser1369Ala): influence on severe hypoglycemia due to sulfonylureas. Pharmacogenomics. 2010 Dec;11(12):1743-1750. DOI: 10.2217/pgs.10.135Sato R., Watanabe H., Genma R., et al. ABCC8 polymorphism (Ser1369Ala): influence on severe hypoglycemia due to sulfonylureas. Pharmacogenomics. 2010 Dec;11(12):1743-1750. DOI: 10.2217/pgs.10.135Li Q., Chen M., Zhang R., et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. Clin Exp Pharmacol Physiol. 2014 Oct;41(10):748-754. DOI: 10.1111/1440-1681Li Q., Chen M., Zhang R., et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. Clin Exp Pharmacol Physiol. 2014 Oct;41(10):748-754. DOI: 10.1111/1440-1681Sesti G., Laratta E., Cardellini M., et al. The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5’-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. J. Clin Endocrinol Metab. 2006 Jun;91(6):2334-2339. DOI: 10.1210/jc.2005-2323Sesti G., Laratta E., Cardellini M., et al. The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5’-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. J. Clin Endocrinol Metab. 2006 Jun;91(6):2334-2339. DOI: 10.1210/jc.2005-2323Holstein A., Hahn M., Stumvoll M., et al. The E23K variant of KCNJ11 and the risk for severe sulfonylurea-induced hypoglycemia in patients with type 2 diabetes. Horm Metab Res. 2009 May;41(5):387-390. DOI: 10.1055/s-0029-1192019Holstein A., Hahn M., Stumvoll M., et al. The E23K variant of KCNJ11 and the risk for severe sulfonylurea-induced hypoglycemia in patients with type 2 diabetes. Horm Metab Res. 2009 May;41(5):387-390. DOI: 10.1055/s-0029-1192019El-Sisi AE, Hegazy sK, Metwally SS, et. al. Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in egyptian patients with type 2 diabetes. Ther Adv Endocrinol Metab. 2011 Aug;2(4):155-164. DOI: 10.1177/2042018811415985El-Sisi AE, Hegazy sK, Metwally SS, et. al. Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in egyptian patients with type 2 diabetes. Ther Adv Endocrinol Metab. 2011 Aug;2(4):155-164. DOI: 10.1177/2042018811415985Feng Y., Mao G., Ren X., et al. Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients. Diabetes Care. 2008 Oct;31(10):1939-1944. DOI: 10.2337/dc07-2248Feng Y., Mao G., Ren X., et al. Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients. Diabetes Care. 2008 Oct;31(10):1939-1944. DOI: 10.2337/dc07-2248Zhang H., Liu X., Kuang H., et al. Association of sulfonylurea receptor 1genotype with therapeutic response to gliclazide in type 2 diabetes. Diabetes Res Clin Pract. 2007 Jul;77(1):58-61. DOI: 10.1016/j.diabres.2006.10.021Zhang H., Liu X., Kuang H., et al. Association of sulfonylurea receptor 1genotype with therapeutic response to gliclazide in type 2 diabetes. Diabetes Res Clin Pract. 2007 Jul;77(1):58-61. DOI: 10.1016/j.diabres.2006.10.021Jamaluddin JL, Huri HZ, Vethakkan SR. Clinical and genetic predictors of dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes mellitus. Pharmacogenomics. 2016 Jun;17(8):867-881. DOI: 10.2217/pgs-2016-0010Jamaluddin JL, Huri HZ, Vethakkan SR. Clinical and genetic predictors of dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes mellitus. Pharmacogenomics. 2016 Jun;17(8):867-881. DOI: 10.2217/pgs-2016-0010Chiang YT, Ip W., Jin T. The role of the Wnt signaling pathway in incretin hormone production and function. Front Physiol. 2012 Jul 12;3:273. DOI: 10.3389/fphys.2012.00273Chiang YT, Ip W., Jin T. The role of the Wnt signaling pathway in incretin hormone production and function. Front Physiol. 2012 Jul 12;3:273. DOI: 10.3389/fphys.2012.00273Xiong X., Shao W., Jin T. New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic ß-cells: the involvement of the Wnt signaling pathway effector ß-catenin. Islets. 2012 Nov-Dec;4(6):359-365. DOI: 10.4161/isl.23345Xiong X., Shao W., Jin T. New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic ß-cells: the involvement of the Wnt signaling pathway effector ß-catenin. Islets. 2012 Nov-Dec;4(6):359-365. DOI: 10.4161/isl.23345Peng S., Zhu Y., L. B., et al. TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated metaanalysis involving 121174 subjects. Mutagenesis. 2013 Jan;28(1):25-37. DOI: 10.1093/mutage/ges048Peng S., Zhu Y., L. B., et al. TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated metaanalysis involving 121174 subjects. Mutagenesis. 2013 Jan;28(1):25-37. DOI: 10.1093/mutage/ges048Kirchhoff K., Machicao F., Haupt A., et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 2008; 51: 597-601.Kirchhoff K., Machicao F., Haupt A., et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 2008; 51: 597-601.Srinivasan S., Kaur V., Chamarthi B., et al. TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care. 2018 Mar;41(3):554-561. DOI: 10.2337/dc17-1386Srinivasan S., Kaur V., Chamarthi B., et al. TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care. 2018 Mar;41(3):554-561. DOI: 10.2337/dc17-1386Махрова И.А., Глотов О.С., Глебова М.А. и др. Эффективность применения метформина при ожирении и метаболическом синдроме у детей и подростков в зависимости от полиморфизма гена TCF7L2 // Медицинская генетика. - 2012. - 4(118). - С. 29-35.Махрова И.А., Глотов О.С., Глебова М.А. и др. Эффективность применения метформина при ожирении и метаболическом синдроме у детей и подростков в зависимости от полиморфизма гена TCF7L2 // Медицинская генетика. - 2012. - 4(118). - С. 29-35.Pearson ER, Donnelly LA, Kimber C., et al. Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes. 2007 Aug;56(8):2178-2182. DOI: 10.2337/db07-0440Pearson ER, Donnelly LA, Kimber C., et al. Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes. 2007 Aug;56(8):2178-2182. DOI: 10.2337/db07-0440Zimdahl H., Ittrich C., Graefe-Mody U., et al. Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin. Diabetologia. 2014 Sep;57(9):1869-1875. DOI: 10.1007/s00125-014-3276-yZimdahl H., Ittrich C., Graefe-Mody U., et al. Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin. Diabetologia. 2014 Sep;57(9):1869-1875. DOI: 10.1007/s00125-014-3276-y

The authors declare that there are no conflicts of interest present.