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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">phgenomics</journal-id><journal-title-group><journal-title xml:lang="ru">Фармакогенетика и фармакогеномика</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacogenetics and Pharmacogenomics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0527</issn><issn pub-type="epub">2686-8849</issn><publisher><publisher-name>LLC "Izdatelstvo OKI"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/2588-0527-2022-2-5-6</article-id><article-id custom-type="elpub" pub-id-type="custom">phgenomics-252</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОГЕНЕТИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOGENETICS STUDY</subject></subj-group></article-categories><title-group><article-title>Влияние гена рецептора аденозина A2AR на риск развития двигательных осложнений длительной леводопа-терапии (моторных флуктуаций и дискинезий) у пациентов с болезнью Паркинсона</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмадеева</surname><given-names>Г. Н.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хидиятова</surname><given-names>И. М.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насибуллин</surname><given-names>Т. Р.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Умутбаев</surname><given-names>С. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галимова</surname><given-names>Р. М.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байтимеров</surname><given-names>А. Р.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Магжанов</surname><given-names>Р. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа</p></bio><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Башкирский государственный медицинский университет Министерства здравоохранения Российской Федерации; Международный медицинский центр им. В.С. Бузаева</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Федеральное государственное бюджетное учреждение науки институт биохимии и генетики Уфимского научного центра Российской академии наук</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Международный медицинский центр им. В.С. Бузаева</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>Общество с ограниченной ответственностью «Национальный медицинский холдинг «Медстандарт»</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-5"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Башкирский государственный медицинский университет Министерства здравоохранения Российской Федерации</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>04</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>5</fpage><lpage>6</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ахмадеева Г.Н., Хидиятова И.М., Насибуллин Т.Р., Умутбаев С.В., Галимова Р.М., Байтимеров А.Р., Магжанов Р.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Ахмадеева Г.Н., Хидиятова И.М., Насибуллин Т.Р., Умутбаев С.В., Галимова Р.М., Байтимеров А.Р., Магжанов Р.В.</copyright-holder><copyright-holder xml:lang="en">Ахмадеева Г.Н., Хидиятова И.М., Насибуллин Т.Р., Умутбаев С.В., Галимова Р.М., Байтимеров А.Р., Магжанов Р.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/252">https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/252</self-uri><abstract><p>Целью нашего исследования является изучения влияния гена рецептора аденозина A2AR на риск развития леводопа-индуцированных дискинезий и моторных флуктуаций у пациентов с болезнью Паркинсона.</p></abstract><kwd-group xml:lang="ru"><kwd>болезнь Паркинсона</kwd><kwd>леводопа</kwd><kwd>двигательные осложнения</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Armentero MT, Levandis G, Bazzini E, et al. 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