phgenomicsФармакогенетика и фармакогеномикаPharmacogenetics and Pharmacogenomics2588-05272686-8849LLC "Izdatelstvo OKI"10.37489/2588-0527-2021-1-38-41phgenomics-219Research ArticleПЕРСПЕКТИВЫ ФАРМАКОГЕНЕТИКИPERSPECTIVE OF PHARMACOGENETICSФармакогенетика противовирусных средств для лечения COVID-19: перспективы для клинической практикиPharmacogenetics of antiviral agents for the treatment of COVID-19https://orcid.org/0000-0002-1242-0833ТемирбулатовИ. И.TemirbulatovI. I.

Темирбулатов Ильяс Ильдарович, аспирант кафедры клинической фармакологии и терапии им. Б.Е. Вотчала; врач клинический фармаколог ГБУЗ «ГКБ № 15 им. О.М. Филатова ДЗМ»

Москва

Temirbulatov Ilyas I., postgraduate student of the Department of Clinical Pharmacology and Therapy named after Academician B.E. Votchal; Clinical Pharmacologist Municipal Clinical Hospital No.15 named O.M. Filatov Department of Health of Moscow

temirbulatov.ilyas@gmail.comhttps://orcid.org/0000-0001-7903-2977КрюковА. В.KryukovA. V.

Крюков Александр Валерьевич, к. м. н., доцент кафедры клинической фармакологии и терапии им. Б.Е. Вотчала; Заведующий отделением клинической фармакологии, врач клинический фармаколог ГБУЗ «ГКБ № 15 им. О.М. Филатова ДЗМ»

Москва

Kryukov Alexander V., Cand. Sci. (Med.), Associate Professor of the Department of Clinical Pharmacology and Therapy named after Academician B.E. Votchal; Head of the Department of Clinical Pharmacology, Clinical Pharmacologist Municipal Clinical Hospital No.15 named O.M. Filatov Department of Health of Moscow

Moscow

alex.kryukov90@yandex.ruhttps://orcid.org/0000-0002-4496-3680СычёвД. А.SychevD. A.

Сычёв Дмитрий Алексеевич, д. м. н., профессор, член-корр. РАН, ректор, зав. кафедрой клинической фармакологии и терапии им. Б.Е. Вотчала

SPIN-код: 4525-7556

Москва

Sychev Dmitry A., Dr. Sci. (Med.), Professor, Corresponding Member RAS, Rector, Head Department of the Clinical Pharmacology and Therapy named after Academician B.E. Votchal

SPIN code: 4525-7556

Moscow

dimasychev@mail.ruФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФРоссияRussian Medical Academy of Continuing Professional Education of the Ministry of Health of RussiaRussian Federation202107012022013841Copyright © Темирбулатов И.И., Крюков А.В., Сычёв Д.А., 20222022Темирбулатов И.И., Крюков А.В., Сычёв Д.А.Temirbulatov I.I., Kryukov A.V., Sychev D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/219

Представлен обзор литературных данных о возможном влиянии фармакогенетических маркеров на эффективность и безопасность этиотропной терапии COVID-19. Рассматриваются клинические исследования ремдесивира и фавипиравира. Исходя из доступных данных о фармакокинетике препаратов описываются потенциальные фармакогенетические маркеры. Отдельно описывается влияние инфекционно-воспалительного процесса на экспрессию ферментов семейства цитохромов

Presented a literature review on the possible influence of pharmacogenetic markers on the efficacy and safety of COVID-19 therapy. Clinical studies of remdesivir and favipiravir are reviewed. Potential pharmacogenetic markers are described based on the available data on the pharmacokinetics of the drugs. We separately described the effect of the infectious-inflammatory process on the expression of cytochrome family enzymes.

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The authors declare that there are no conflicts of interest present.