phgenomicsФармакогенетика и фармакогеномикаPharmacogenetics and Pharmacogenomics2588-05272686-8849LLC "Izdatelstvo OKI"10.37489/2588-0527-2021-1-9-17phgenomics-218Research ArticleАКТУАЛЬНЫЕ ОБЗОРЫCURRENT REVIEWПолиморфизм гена ADRB2 и состояние угрозы преждевременных родовADRB2 gene polymorphism and preterm laborhttps://orcid.org/0000-0003-0802-4229КазаковР. Е.KazakovR. E.

Казаков Руслан Евгеньевич, к. б. н., начальник отдела персонализированной медицины и клинической фармакогенетики

Москва

Kazakov Ruslan Ye., Cand. Sci. (Biol.), Head of the Department of Personalized Medicine and Clinical Pharmacogenetics CCP

Moscow

rustic100@rambler.ruhttps://orcid.org/0000-0001-6331-3109ЧиловаР. А.ChilovaR. A.

Чилова Раиса Алексеевна, д. м. н., доцент, профессор кафедры акушерства и гинекологии

Москва

Chilova Raisa A., Dr. Sci. (Med.), Associate Professor, Professor of the Department of Obstetrics and Gynecology

Moscow

rtchilova@gmail.comhttps://orcid.org/0000-0002-3268-481XАкоповК. О.AkopovK. O.

Акопов Константин Олегович, врач акушер-гинеколог

Москва

Akopov Konstantin O., doctor obstetrician-gynecologist

Moscow

akopovkonstantin@mail.ruhttps://orcid.org/0000-0002-6389-2099СоковаЕ. А.SokovaE. A.

Сокова Елена Андреевна, к. м. н., доцент; ведущий аналитик

Москва

Sokova Elena A., Cand. Sci. (Med.), Associate Professor; lead analyst CCP

Moscow

rtchilova@gmail.comФГБУ «НЦЭСМП» Минздрава России; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФРоссияFSBI «SCEEMP» of the Ministry of Health of the Russian Federation; Russian Medical Academy of Continuing Professional EducationRussian FederationФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияRussian Medical Academy of Continuing Professional EducationRussian FederationГосударственное бюджетное учреждение здравоохранения города Москвы «Городская клиническая больница имени С.С. Юдина Департамента здравоохранения города Москвы» ДЗМ ЖК № 3РоссияS.S. Yudin State Clinical Hospital of the Moscow Department of Health Care» women’s consultation No. 3Russian FederationФГБУ «НЦЭСМП» Минздрава России; ФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияFSBI «SCEEMP» of the Ministry of Health of the Russian Federation; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian Federation20210701202201917Copyright © Казаков Р.Е., Чилова Р.А., Акопов К.О., Сокова Е.А., 20222022Казаков Р.Е., Чилова Р.А., Акопов К.О., Сокова Е.А.Kazakov R.E., Chilova R.A., Akopov K.O., Sokova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/218

В данной статье обсуждаются вопросы, связанные с ролью полиморфизма гена ADRB2, кодирующего β2-адренорецептор, при преждевременных родах и токолизе. Приводится информация о научных исследованиях по поиску ассоциаций носительства аллелей и генотипов ADRB2 с состоянием угрозы преждевременных родов, с самопроизвольными преждевременными родами, а также с фармакологическим ответом на токолитическую терапию с помощью β2-адреномиметиков. В хронологическом порядке изложена история открытия взаимосвязи полиморфизма гена ADRB2 с преждевременными родами. По мере появления научных фактов, перед исследователями возникает вопрос: каким образом полиморфизмы гена ADRB2 могут отражаться на физиологических процессах? То есть, влияют ли они посредством изменения первичной структуры рецептора или же посредством изменения уровня экспрессии. В зависимости от ответа на этот вопрос перед фармакогенетиками ставится дальнейшая задача: что изучать – отдельные полиморфизмы или гаплотипы?

This article discusses issues related to the role of polymorphism of the ADRB2 gene encoding β2-adrenergic receptor in preterm labor and tocolysis. Information is provided on scientific studies related to the search for associations of the carriage of alleles and genotypes of ADRB2 with the preterm labor, as well as with the pharmacological response to tocolytic therapy using β2-adrenergic agonists. The history of the discovery of the relationship of ADRB2 gene polymorphisms with preterm labor is presented in chronological order. As scientific facts emerge, researchers are faced with the question: how can ADRB2 gene polymorphisms affect physiological processes? That is, whether they affect by changing the primary structure of the receptor or by changing the level of expression. Depending on the answer to this question, pharmacogenetics are faced with a further task: what to study - individual polymorphisms or haplotypes?

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The authors declare that there are no conflicts of interest present.