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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">phgenomics</journal-id><journal-title-group><journal-title xml:lang="ru">Фармакогенетика и фармакогеномика</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacogenetics and Pharmacogenomics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0527</issn><issn pub-type="epub">2686-8849</issn><publisher><publisher-name>LLC "Izdatelstvo OKI"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/2588-0527-2020-2-19-20</article-id><article-id custom-type="elpub" pub-id-type="custom">phgenomics-199</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОГЕНЕТИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOGENETICS STUDY</subject></subj-group></article-categories><title-group><article-title>Влияние носительства клинически значимых аллельных вариантов генов CES1, PON1, ABCG2, CYP4F2, CYP3A4, IGTB3, P2Y12, PEAR1, B4GALT2 на антиагрегантное действие клопидогрела и клинические исходы пациентов с ОКС и фибрилляцией предсердий</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федина</surname><given-names>Л. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирзаев</surname><given-names>К. Б.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычёв</surname><given-names>Д. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Батурина</surname><given-names>О. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыткин</surname><given-names>Э.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иващенко</surname><given-names>Д. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреев</surname><given-names>Д. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыжикова</surname><given-names>К. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришина</surname><given-names>Е. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бочков</surname><given-names>П. О.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевченко</surname><given-names>Р. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФ</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>24</day><month>02</month><year>2021</year></pub-date><volume>0</volume><issue>2</issue><fpage>19</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Федина Л.В., Мирзаев К.Б., Сычёв Д.А., Батурина О.А., Рыткин Э., Иващенко Д.В., Андреев Д.А., Рыжикова К.А., Гришина Е.А., Бочков П.О., Шевченко Р.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Федина Л.В., Мирзаев К.Б., Сычёв Д.А., Батурина О.А., Рыткин Э., Иващенко Д.В., Андреев Д.А., Рыжикова К.А., Гришина Е.А., Бочков П.О., Шевченко Р.В.</copyright-holder><copyright-holder xml:lang="en">Федина Л.В., Мирзаев К.Б., Сычёв Д.А., Батурина О.А., Рыткин Э., Иващенко Д.В., Андреев Д.А., Рыжикова К.А., Гришина Е.А., Бочков П.О., Шевченко Р.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/199">https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/199</self-uri><abstract><p>.</p></abstract><kwd-group xml:lang="ru"><kwd>полиморфизм генов</kwd><kwd>клопидогрел</kwd><kwd>острый коронарный синдром</kwd><kwd>фибрилляция предсердий</kwd><kwd>CYP2C19</kwd><kwd>фармакогенетическое тестирование</kwd><kwd>чрескожное коронарное вмешательство</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Simon T, Steg PG, Becquemont L et al. 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