phgenomicsФармакогенетика и фармакогеномикаPharmacogenetics and Pharmacogenomics2588-05272686-8849LLC "Izdatelstvo OKI"10.37489/2588-0527-2021-1-18-23phgenomics-190Research ArticleКЛИНИЧЕСКАЯ ФАРМАКОГЕНЕТИКАCLINICAL PHARMACOGENETICSГенетические предпосылки снижения концентрации токоферола в сыворотке кровиGenetic prerequisites for reducing serum tocopherol concentrationhttps://orcid.org/0000-0001-9513-0366ЗеленскаяЕ. М.ZelenskayaE. M.

Зеленская Елена Михайловна, м. н. с. Лаборатории персонализированной медицины

Новосибирск

Zelenskaya Elena M., Junior Researcher of the Laboratory for Personalized Medicine

Novosibirsk

helenzlnsk@gmail.comhttps://orcid.org/0000-0001-9048-7710ЛифшицГ. И.LifshitsG. I.

Лифшиц Галина Израилевна, д. м. н., профессор, заведующая лабораторией персонализированной медицины

SPIN-код: 9704-1601

Новосибирск

Lifshits Galina I., Dr. Sci. (Med.), professor, head of the laboratory of personalized medicine

Novosibirsk

Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН)РоссияFederal State Budgetary Institution of Science Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences (ICBFM SB RAS)Russian Federation202106022021011823Copyright © Зеленская Е.М., Лифшиц Г.И., 20222022Зеленская Е.М., Лифшиц Г.И.Zelenskaya E.M., Lifshits G.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/190

Проведён анализ данных литературы по генетическим маркерам, ассоциированным со снижением активной формы витамина Е в сыворотке крови. Также рассмотрены современные рекомендации по питанию и медикаментозному лечению гиповитаминоза Е.

Тhis review is based on literature data analysis on genetic markers associated with vitamin E metabolism. We focus on the SNPs associated with different pathologic conditions: a decrease of active form of vitamin E in serum. Also reviewed the current recommendations on nutrition and drug treatment of hypovitaminosis.

витамин Еα-TTPСYP4F2ZNF259SCARB1токоферолтокотриенолvitamin Еα-TTPСYP4F2ZNF259SCARB1tocopheroltocotrienolReferencesChin KY, Pang KL, Soelaiman IN. Tocotrienol and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:97–130. DOI: 10.1007/978-3-319-41334-1_5.Chin KY, Pang KL, Soelaiman IN. Tocotrienol and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:97–130. DOI: 10.1007/978-3-319-41334-1_5.Idriss M, Hodroj MH, Fakhoury R, Rizk S. Beta-Tocotrienol Exhibits More Cytotoxic Effects than Gamma-Tocotrienol on Breast Cancer Cells by Promoting Apoptosis via a P53-Independent PI3-Kinase Dependent Pathway. Biomolecules. 2020 Apr 9;10(4):577. DOI: 10.3390/biom10040577.Idriss M, Hodroj MH, Fakhoury R, Rizk S. Beta-Tocotrienol Exhibits More Cytotoxic Effects than Gamma-Tocotrienol on Breast Cancer Cells by Promoting Apoptosis via a P53-Independent PI3-Kinase Dependent Pathway. Biomolecules. 2020 Apr 9;10(4):577. DOI: 10.3390/biom10040577.Mohd Zaffarin AS, Ng SF, Ng MH, Hassan H, Alias E. Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability. Int J Nanomedicine. 2020;15:9961–9974. DOI: 10.2147/IJN.S276355.Mohd Zaffarin AS, Ng SF, Ng MH, Hassan H, Alias E. Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability. Int J Nanomedicine. 2020;15:9961–9974. DOI: 10.2147/IJN.S276355.Major JM, Yu K, Weinstein SJ, et al. Genetic variants reflecting higher vitamin Е status in men are associated with reduced risk of prostate cancer. J Nutr. 2014;144(5):729–733. DOI: 10.3945/jn.113.189928.Major JM, Yu K, Weinstein SJ, et al. Genetic variants reflecting higher vitamin Е status in men are associated with reduced risk of prostate cancer. J Nutr. 2014;144(5):729–733. DOI: 10.3945/jn.113.189928.Major JM, Yu K, Wheeler W, Zhang H, Cornelis MC, Wright ME, Yeager M, Snyder K, Weinstein SJ, Mondul A, Eliassen H, Purdue M, Hazra A, McCarty CA, Hendrickson S, Virtamo J, Hunter D, Chanock S, Kraft P, Albanes D. Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum Mol Genet. 2011 Oct 1;20(19):3876–3883. DOI: 10.1093/hmg/ddr296.Major JM, Yu K, Wheeler W, Zhang H, Cornelis MC, Wright ME, Yeager M, Snyder K, Weinstein SJ, Mondul A, Eliassen H, Purdue M, Hazra A, McCarty CA, Hendrickson S, Virtamo J, Hunter D, Chanock S, Kraft P, Albanes D. Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum Mol Genet. 2011 Oct 1;20(19):3876–3883. DOI: 10.1093/hmg/ddr296.Диетология. 5-е изд. / под ред. А. Ю. Барановского. – СПб.: Питер; 2017. – 1104 с.Dietetics. 5th ed. / Edited by A. Y. Baranovsky. St. Petersburg: Peter; 2017. (In Russ).Major JM, Yu K, Chung CC, Weinstein SJ, Yeager M, Wheeler W, Snyder K, Wright ME, Virtamo J, Chanock S, Albanes D. Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. J Nutr. 2012 May;142(5):866–871. DOI: 10.3945/jn.111.156349.Major JM, Yu K, Chung CC, Weinstein SJ, Yeager M, Wheeler W, Snyder K, Wright ME, Virtamo J, Chanock S, Albanes D. Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. J Nutr. 2012 May;142(5):866–871. DOI: 10.3945/jn.111.156349.Hentati A, Deng HX, Hung WY, Nayer M, Ahmed MS, He X, Tim R, Stumpf DA, Siddique T. Human α-tocopherol transfer protein: Gene structure and mutations in familial vitamin E deficiency. Ann Neurol. 1996;39(3):295–300. DOI: 10.1002/ana.410390305.Hentati A, Deng HX, Hung WY, Nayer M, Ahmed MS, He X, Tim R, Stumpf DA, Siddique T. Human α-tocopherol transfer protein: Gene structure and mutations in familial vitamin E deficiency. Ann Neurol. 1996;39(3):295–300. DOI: 10.1002/ana.410390305.Manor D, Morley S. The alpha-tocopherol transfer protein. Vitam Horm. 2007;76:45–65. DOI: 10.1016/S0083-6729(07)76003-X. PMID: 17628171.Manor D, Morley S. The alpha-tocopherol transfer protein. Vitam Horm. 2007;76:45–65. DOI: 10.1016/S0083-6729(07)76003-X. PMID: 17628171.Bardowell SA, Stec DE, Parkerм RS. Common Variants of Cytochrome P450 4F2 Exhibit Altered Vitamin E-ω-Hydroxylase Specific Activity. J Nutr. 2010 Nov;140(11):1901–1906. DOI: 10.3945/jn.110.128579.Bardowell SA, Stec DE, Parkerм RS. Common Variants of Cytochrome P450 4F2 Exhibit Altered Vitamin E-ω-Hydroxylase Specific Activity. J Nutr. 2010 Nov;140(11):1901–1906. DOI: 10.3945/jn.110.128579.Stec DE, Roman RJ, Flasch A, Rieder MJ. Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiol Genomics. 2007 Jun 19;30(1):74–81. DOI: 10.1152/physiolgenomics.00003.2007.Stec DE, Roman RJ, Flasch A, Rieder MJ. Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiol Genomics. 2007 Jun 19;30(1):74–81. DOI: 10.1152/physiolgenomics.00003.2007.Wang T, Xu L. Circulating Vitamin E Levels and Risk of Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study. Nutrients. 2019 Sep 9;11(9):2153. DOI: 10.3390/nu11092153.Wang T, Xu L. Circulating Vitamin E Levels and Risk of Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study. Nutrients. 2019 Sep 9;11(9):2153. DOI: 10.3390/nu11092153.Schmölz L, Birringer M, Lorkowski S, Wallert M. Complexity of vitamin E metabolism. World J Biol Chem. 2016;7(1):14–43. DOI: 10.4331/wjbc.v7.i1.14.Schmölz L, Birringer M, Lorkowski S, Wallert M. Complexity of vitamin E metabolism. World J Biol Chem. 2016;7(1):14–43. DOI: 10.4331/wjbc.v7.i1.14.Витамин Е официальная инструкция к препарату. Доступно по: https://www.vidal.ru/drugs/vitamin_e__40813. Ссылка активна на 19.01.2021.Vitamin E official instructions for the drug. (In Russ). Доступно по: https://www.vidal.ru/drugs/vitamin_e__40813. Ссылка активна на 19.01.2021.Лифшиц Г.И., Филипенко М.Л., Шевела А.И. Персонализированная медицина. лечить не болезнь, а больного. Наука из первых рук. 2012;44(2):58–65.Lifshits GI, Filipenko ML, Shevela AI. Personalized medicine. to treat not a disease, but a patient. First hand science. 2012;44(2):58–65. (In Russ).Зеленская Е.М., Кох Н.В., Слепухина А.А., Лифшиц Г.И. Нутригенетический тест в клинической практике: цели и возможности. Клиническая практика. 2017;31(3):76–82.Zelenskaya EM, Kokh NV, Slepukhina AA, Lifshits GI. Nutrigenetic test in clinical practice: goals and opportunities. Clinical practice. 2017;31(3):76–82. (In Russ)

The authors declare that there are no conflicts of interest present.