phgenomicsФармакогенетика и фармакогеномикаPharmacogenetics and Pharmacogenomics2588-05272686-8849LLC "Izdatelstvo OKI"10.37489/2588-0527-2020-1-11-18phgenomics-185Research ArticleТЕРАПЕВТИЧЕСКИЙ ЛЕКАРСТВЕННЫЙ МОНИТОРИНГTHERAPEUTIC DRUG MONITORINGПути оптимизации применения статинов: генетические факторы и терапевтический лекарственный мониторингOptimization of statin use: genetic factors and therapeutic drug monitoringhttps://orcid.org/0000-0003-0802-4229КазаковР. Е.KazakovR. Ye.

Казаков Руслан Евгеньевич - к. б. н., начальник отдела Персонализированной медицины и клинической фармакогенетики

Москва

Kazakov Ruslan Ye. - Candidate of Biology Sciences, head of the Department of Personalized medicine and clinical pharmacogenetics 

Moscow

https://orcid.org/0000-0001-7024-5546ПрокофьевА. Б.ProkofievA. B.

Прокофьев Алексей Борисович - д. м. н., профессор, директор Центра клинической фармакологии

Москва

Moscow

Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииРоссияCCP FSBI «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationRussian Federation202030062020011118Copyright © Казаков Р.Е., Прокофьев А.Б., 20202020Казаков Р.Е., Прокофьев А.Б.Kazakov R.Y., Prokofiev A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/185

Статья посвящена описанию мирового опыта персонализированного назначения статинов. Изложены предпосылки включения в алгоритм назначения статинов учета генетического фактора – носительство аллеля c.521С гена SLCO1B1, а также описаны причины, затрудняющие внедрение терапевтического лекарственного мониторинга статинов в клиническую практику..

The article is devoted to the description of the global experience of personalized prescription of statins. The prerequisites for including the genetic factor, the carriage of the c.521C allele of the gene SLCO1B1, into the statin prescribing algorithm are stated. Also set out the reasons that complicate the introduction of therapeutic drug monitoring of statins into clinical practice are described.

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The authors declare that there are no conflicts of interest present.