<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">phgenomics</journal-id><journal-title-group><journal-title xml:lang="ru">Фармакогенетика и фармакогеномика</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacogenetics and Pharmacogenomics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0527</issn><issn pub-type="epub">2686-8849</issn><publisher><publisher-name>LLC "Izdatelstvo OKI"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">phgenomics-176</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDY</subject></subj-group></article-categories><title-group><article-title>Сопоставление активности изофермента цитохрома Р450 CYP2C9 у пациентов пожилого и старческого возраста и у здоровых добровольцев первого периода зрелого возраста</article-title><trans-title-group xml:lang="en"><trans-title>Comparative analysis of cytochrome P450 isoform CYP2C9 in elderly and senile patients with that in healthy volunteers of the first period of middle age</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычёв</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sychev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бордовский</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Bordovsky</surname><given-names>S. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бордовский Сергей Петрович – студент 5 курса.</p><p>тел. +7 (967) 269-16-47</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Arhont7@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никулин</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikulin</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Польшина</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Polshina</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аникин</surname><given-names>Г. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Anikin</surname><given-names>G. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данилина</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilina</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Отделенов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Otdelenov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ДПО Российская медицинская академия непрерывного профессионального образования Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBEI FPE Russian Medical Academy of Continuous Professional Education of Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Первый МГМУ им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University named after I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Первый МГМУ им. И.М. Сеченова; Институт иммунологии ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University named after I.M. Sechenov; NRC Institute of Immunology FMBA of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>25</day><month>03</month><year>2020</year></pub-date><volume>0</volume><issue>2</issue><fpage>19</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сычёв Д.А., Бордовский С.П., Никулин В.Э., Польшина Н.И., Аникин Г.С., Данилина К.С., Смирнов В.В., Отделенов В.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Сычёв Д.А., Бордовский С.П., Никулин В.Э., Польшина Н.И., Аникин Г.С., Данилина К.С., Смирнов В.В., Отделенов В.А.</copyright-holder><copyright-holder xml:lang="en">Sychev D.A., Bordovsky S.P., Nikulin V.E., Polshina N.I., Anikin G.S., Danilina K.S., Smirnov V.V., Otdelenov V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/176">https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/176</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>лекарственная терапия</kwd><kwd>CYP2C9</kwd><kwd>лозартан</kwd><kwd>пожилые пациенты</kwd><kwd>пациенты старческого возраста</kwd></kwd-group><kwd-group xml:lang="en"><kwd>drug therapy</kwd><kwd>CYP2C9 isoform</kwd><kwd>losartan</kwd><kwd>elderly people</kwd><kwd>senile people</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Osadchih A.I., Puzin S.N., Lavrova D.I. et al. Problems of disability in Russia. State and prospects; Medicine, 2002: 368.</mixed-citation><mixed-citation xml:lang="en">Osadchih A.I., Puzin S.N., Lavrova D.I. et al. Problems of disability in Russia. State and prospects; Medicine, 2002: 368.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Denisova T.P., Malinova L.I. Clinical Gerontology: Selected Lectures. Moscow: LLC ‘Medical information agency’, 2008: 256.</mixed-citation><mixed-citation xml:lang="en">Denisova T.P., Malinova L.I. Clinical Gerontology: Selected Lectures. Moscow: LLC ‘Medical information agency’, 2008: 256.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Page K., Curtis M., Woker B., Hoffman B. Pharmacology: a clinical approach. Moscow: Logospheraю 2012: 744.</mixed-citation><mixed-citation xml:lang="en">Page K., Curtis M., Woker B., Hoffman B. Pharmacology: a clinical approach. Moscow: Logospheraю 2012: 744.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Belousov U.B., Leonova M.V. Special aspects of drug therapy in geriartric practice. Pharmatekaю 2008; 8; 13–19.</mixed-citation><mixed-citation xml:lang="en">Belousov U.B., Leonova M.V. Special aspects of drug therapy in geriartric practice. Pharmatekaю 2008; 8; 13–19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Scordo M.G., Pengo V., Spina E., Dahl M.L., Gusella M., Padrini R. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther. 2002; 72; 702–710.</mixed-citation><mixed-citation xml:lang="en">Scordo M.G., Pengo V., Spina E., Dahl M.L., Gusella M., Padrini R. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther. 2002; 72; 702–710.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Klotz U. The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications. Clin Pharmacokine.t 2007; 46; 271–279.</mixed-citation><mixed-citation xml:lang="en">Klotz U. The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications. Clin Pharmacokine.t 2007; 46; 271–279.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Shi S., Klotz U. Clinical use and pharmacological properties of selective COX-2 inhibitors. Eur J Clin Pharmacol 2008; 64; 233–252.</mixed-citation><mixed-citation xml:lang="en">Shi S., Klotz U. Clinical use and pharmacological properties of selective COX-2 inhibitors. Eur J Clin Pharmacol 2008; 64; 233–252.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jetter A., Kinzig-Schippers M., Skott A. Cytochrome P450 2C9 phenotyping using low-dose tolbutamide. Eur J Clin Pharmaco.l 2004; 60: 3; 165–171.</mixed-citation><mixed-citation xml:lang="en">Jetter A., Kinzig-Schippers M., Skott A. Cytochrome P450 2C9 phenotyping using low-dose tolbutamide. Eur J Clin Pharmaco.l 2004; 60: 3; 165–171.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">George M., Shewade D.G., Kumar S.V., Adithan C. Effect of antituberculosis therapy on polymorphic drug metabolizing enzyme CYP2C9 using phenytoin as a probe drug. Indian J Pharmacol. 2012; 44; 4: 485–488.</mixed-citation><mixed-citation xml:lang="en">George M., Shewade D.G., Kumar S.V., Adithan C. Effect of antituberculosis therapy on polymorphic drug metabolizing enzyme CYP2C9 using phenytoin as a probe drug. Indian J Pharmacol. 2012; 44; 4: 485–488.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sychev D.A. Russian guidelines for studying biotransformation and new drug transporter testing by pharmaceutical companies: study desings, data analysis, data entry in products’ instructions. Available at: URL: http://www.regmed.ru/Content/Doc.aspx?id=26a9128c-ee32-4469-9c64-5c666339049e</mixed-citation><mixed-citation xml:lang="en">Sychev D.A. Russian guidelines for studying biotransformation and new drug transporter testing by pharmaceutical companies: study desings, data analysis, data entry in products’ instructions. Available at: URL: http://www.regmed.ru/Content/Doc.aspx?id=26a9128c-ee32-4469-9c64-5c666339049e</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Joy M.S., Dornbrook-Lavender K., Blaisdell J., Hilliard T., Boyette T., Hu Y., Hogan S.L., Candiani C., Falk R.J., Goldstein J.A. CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases. Clin Pharmacol. 2009; 65: 9: 947–953.</mixed-citation><mixed-citation xml:lang="en">Joy M.S., Dornbrook-Lavender K., Blaisdell J., Hilliard T., Boyette T., Hu Y., Hogan S.L., Candiani C., Falk R.J., Goldstein J.A. CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases. Clin Pharmacol. 2009; 65: 9: 947–953.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tanaka E. In vivo age-related changes in hepatic drug-oxidizing capacity in humans. Journal of Clin Pharmacy and Therapeutics. 1998; 23; 247–255.</mixed-citation><mixed-citation xml:lang="en">Tanaka E. In vivo age-related changes in hepatic drug-oxidizing capacity in humans. Journal of Clin Pharmacy and Therapeutics. 1998; 23; 247–255.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
