phgenomicsФармакогенетика и фармакогеномикаPharmacogenetics and Pharmacogenomics2588-05272686-8849LLC "Izdatelstvo OKI"10.24411/2588-0527-2019-10036phgenomics-145Research ArticleПЕРСПЕКТИВЫ ФАРМАКОГЕНЕТИКИPERSPECTIVE OF PHARMACOGENETICSГенетические предпосылки снижения концентрации ретинола в сыворотке кровиGenetic prerequisites for reducing serum retinol concentrationhttps://orcid.org/0000-0001-9513-0366ЗеленскаяЕ. М.ZelenskayaE. M.

Зеленская Елена Михайловна – м. н. с. лаборатории персонализированной медицины. SPIN-код: 5792-0076

Новосибирск

Zelenskaia Elena – junior researcher laboratories of personalized medicine. SPIN-code: 5792-0076

Novosibirsk

helenzlnsk@gmail.comhttps://orcid.org/0000-0001-9048-7710ЛифшицГ. И.LifshitsG. I.

Лифшиц Галина Израилевна – д. м. н., профессор, заведующая лабораторией персонализированной медицины. SPIN-код: 9704-1601

Новосибирск

Lifshits Galina – MD, professor, head of the laboratory of personalized medicine. SPIN-code: 9704-1601

Novosibirsk

Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН)РоссияInstitute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences (ICBFM SB RAS)Russian Federation201923032020011216Copyright © Зеленская Е.М., Лифшиц Г.И., 20192019Зеленская Е.М., Лифшиц Г.И.Zelenskaya E.M., Lifshits G.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/145

В данной статье рассматривается метаболизм витамина А, значимые гены, играющие важную роль в метаболизме витамина А и однонуклеотидные замены в них, ассоциированные с пониженной концентрацией витамина А в крови и различными заболеваниями. Также рассмотрены современные рекомендации по питанию и медикаментозному лечению гиповитаминоза А.

This article discusses the metabolism of vitamin A, significant genes that play an important role in the metabolism of vitamin A and single-nucleotide substitutions in them, associated with a low concentration of vitamin A in the blood and various diseases. Also reviewed the current recommendations on nutrition and drug treatment of hypovitaminosis.

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The authors declare that there are no conflicts of interest present.