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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">phgenomics</journal-id><journal-title-group><journal-title xml:lang="ru">Фармакогенетика и фармакогеномика</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacogenetics and Pharmacogenomics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0527</issn><issn pub-type="epub">2686-8849</issn><publisher><publisher-name>LLC "Izdatelstvo OKI"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24411/2588-0527-2019-10047</article-id><article-id custom-type="elpub" pub-id-type="custom">phgenomics-122</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОГЕНЕТИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOGENETICS STUDY</subject></subj-group></article-categories><title-group><article-title>Исследование полиморфизма генов системы регуляции артериального давления, транспортера SLCO1B1 и карбоксилэстеразы 1 (CES1) у больных артериальной гипертензией, принимающих эналаприл</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иконникова</surname><given-names>А. Ю.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селяева</surname><given-names>Л. С.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наседкина</surname><given-names>Т. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Родина</surname><given-names>Т. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельников</surname><given-names>Е. С.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>А. И.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казаков</surname><given-names>Р. Е.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУН Институт молекулярной биологии им. В.А. Энгельгардта Российской академии наук (ИМБ РАН)</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГБУ «Научный центр экспертизы средств медицинского применения» Минздрава России (ФГБУ НЦЭСМП)</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>22</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>2</issue><fpage>13</fpage><lpage>15</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иконникова А.Ю., Селяева Л.С., Наседкина Т.В., Родина Т.А., Мельников Е.С., Дмитриев А.И., Казаков Р.Е., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Иконникова А.Ю., Селяева Л.С., Наседкина Т.В., Родина Т.А., Мельников Е.С., Дмитриев А.И., Казаков Р.Е.</copyright-holder><copyright-holder xml:lang="en">Иконникова А.Ю., Селяева Л.С., Наседкина Т.В., Родина Т.А., Мельников Е.С., Дмитриев А.И., Казаков Р.Е.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/122">https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/122</self-uri><abstract><p>Определение распространённости аллельных вариантов генов системы регуляции АД, а также генов, участвующих в транспорте и метаболизме эналаприла у пациентов с артериальной гипертензией, принимающих эналаприл.</p><p> </p></abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>эналаприл</kwd><kwd>ген CES1</kwd><kwd>ген SLCO1B1</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tarkiainen EK, Tornio A, Holmberg MT et al. 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