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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">phgenomics</journal-id><journal-title-group><journal-title xml:lang="ru">Фармакогенетика и фармакогеномика</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacogenetics and Pharmacogenomics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0527</issn><issn pub-type="epub">2686-8849</issn><publisher><publisher-name>LLC "Izdatelstvo OKI"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">phgenomics-12</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ФАРМАКОГЕНЕТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL PHARMACOGENETICS</subject></subj-group></article-categories><title-group><article-title>Фармакогенетика нового орального антикоагулянта дабигатрана - роль полиморфизма rs2244613 CES1 в развитии нежелательных побочных реакций</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мещеряков</surname><given-names>Ю. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чертовских</surname><given-names>Я. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычёв</surname><given-names>Д. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ДПО Российская Медицинская Академия Непрерывного Профессионального Образования МЗ РФ; ГБОУ ВПО Первый МГМУ им. И.М. Сеченова МЗ РФ</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Центр персонализированной медицины ГБУ «Республиканская больница № 3» Республики Саха</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>ФГБОУ ДПО Российская Медицинская Академия Непрерывного Профессионального Образования МЗ РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>12</day><month>12</month><year>2017</year></pub-date><volume>0</volume><issue>2</issue><fpage>18</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мещеряков Ю.В., Чертовских Я.В., Сычёв Д.А., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Мещеряков Ю.В., Чертовских Я.В., Сычёв Д.А.</copyright-holder><copyright-holder xml:lang="en">Мещеряков Ю.В., Чертовских Я.В., Сычёв Д.А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/12">https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/12</self-uri><abstract/><kwd-group xml:lang="ru"><kwd>ген CES1</kwd><kwd>гематурия</kwd><kwd>системный тромбоз</kwd><kwd>дабигатран</kwd><kwd>антикоагулянтная терапия</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dimatteo C., D’Andrea G., Vecchione G., Paoletti O., Cappucci F., Tiscia G.L. et al. Pharmacogenetics of dabigatran etexilate interindividual variability. Thromb. Res., 2016, 144: 1-5.</mixed-citation><mixed-citation xml:lang="en">Dimatteo C., D’Andrea G., Vecchione G., Paoletti O., Cappucci F., Tiscia G.L. et al. Pharmacogenetics of dabigatran etexilate interindividual variability. Thromb. Res., 2016, 144: 1-5.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Par G., Eriksson N., Lehr T., Connolly S., Eikelboom J., Ezekowitz M. et al. Genetic determinants of dabigatran plasma levels and their relation to bleeding. Circulation 2013, 127: 1404-1412.</mixed-citation><mixed-citation xml:lang="en">Par G., Eriksson N., Lehr T., Connolly S., Eikelboom J., Ezekowitz M. et al. Genetic determinants of dabigatran plasma levels and their relation to bleeding. Circulation 2013, 127: 1404-1412.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
