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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">phgenomics</journal-id><journal-title-group><journal-title xml:lang="ru">Фармакогенетика и фармакогеномика</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacogenetics and Pharmacogenomics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0527</issn><issn pub-type="epub">2686-8849</issn><publisher><publisher-name>LLC "Izdatelstvo OKI"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">phgenomics-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ФАРМАКОГЕНЕТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL PHARMACOGENETICS</subject></subj-group></article-categories><title-group><article-title>Полиморфизм CYP3A5*3 и особенности метаболизма ингибиторов протонной помпы у пациентов с язвенной болезнью</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макушина</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисенко</surname><given-names>Н. П.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычёв</surname><given-names>Д. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыжикова</surname><given-names>К. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Созаева</surname><given-names>Ж. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришина</surname><given-names>Е. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава РФ (Сеченовский университет)</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГБОУ ДПО РМАНПО Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>12</day><month>12</month><year>2017</year></pub-date><volume>0</volume><issue>2</issue><fpage>17</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Макушина А.А., Денисенко Н.П., Сычёв Д.А., Рыжикова К.А., Созаева Ж.А., Гришина Е.А., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Макушина А.А., Денисенко Н.П., Сычёв Д.А., Рыжикова К.А., Созаева Ж.А., Гришина Е.А.</copyright-holder><copyright-holder xml:lang="en">Макушина А.А., Денисенко Н.П., Сычёв Д.А., Рыжикова К.А., Созаева Ж.А., Гришина Е.А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/11">https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/view/11</self-uri><abstract/><kwd-group xml:lang="ru"><kwd>распространённость</kwd><kwd>полиморфизм CYP3A5*3</kwd><kwd>язвенная болезнь желудка и двенадцатиперстной кишки</kwd><kwd>омепразол</kwd><kwd>ингибиторы протонной помпы</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y., Zhang W., Guo D., Zhou G., Zhou H., Xiao Z. Pharmacokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes. Clinica Chimica Acta, 2008, 391: 60-67.</mixed-citation><mixed-citation xml:lang="en">Li Y., Zhang W., Guo D., Zhou G., Zhou H., Xiao Z. Pharmacokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes. Clinica Chimica Acta, 2008, 391: 60-67.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sugimoto K., Uno T., Tateishi T. Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs. Eur J Clin Pharmacol, 2008, 64: 583-587.</mixed-citation><mixed-citation xml:lang="en">Sugimoto K., Uno T., Tateishi T. 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